TF-Drugs

The table lists druggable TFs and approved drugs, which are extracted from the DrugBank database. 20 out of 32 druggable TFs are available in the SM-TF database.

TF name Gene UniProt Drugs [DrugBank] SM-TF
Androgen receptor AR P10275 DB00367, DB00421, DB00499, DB00621, DB00624, DB00665, DB00687, DB00858, DB00984, DB01128, DB01185, DB01395, DB01406, DB01420, DB04839, DB06710, DB08804, DB08899 Y
Aryl hydrocarbon receptor AHR P35869 DB00379, DB00499, DB01076, DB01097, DB01404 N
Bile acid receptor NR1H4 Q96RI1 DB06777 Y
Cyclic AMP-responsive element-binding protein 1 CREB1 P16220 DB00131, DB01183 N
DNA (cytosine-5)-methyltransferase 1 DNMT1 P26358 DB00928, DB01035, DB01099, DB01262 N
Estrogen receptor ESR1 P03372 DB00255, DB00269, DB00286, DB00294, DB00304, DB00367, DB00396, DB00481, DB00539, DB00603, DB00655, DB00675, DB00783, DB00823, DB00882, DB00890, DB00947, DB00957, DB00977, DB01065, DB01108, DB01183, DB01185, DB01196, DB01357, DB01406, DB01431, DB04573, DB04574, DB04575, DB04938 Y
Estrogen receptor beta ESR2 Q92731 DB00255, DB00481, DB00675, DB00783, DB01108, DB01196, DB04573, DB04574 Y
Estrogen-related receptor gamma ESRRG P62508 DB00255 Y
Glucocorticoid receptor NR3C1 P04150 DB00180, DB00223, DB00240, DB00253, DB00288, DB00324, DB00351, DB00394, DB00443, DB00547, DB00588, DB00591, DB00596, DB00620, DB00635, DB00663, DB00687, DB00741, DB00764, DB00769, DB00834, DB00838, DB00846, DB00860, DB00873, DB00896, DB00959, DB01013, DB01047, DB01130, DB01185, DB01222, DB01234, DB01260, DB01380, DB01384, DB01410, DB06781, DB08906 Y
Mineralocorticoid receptor NR3C2 P08235 DB00393, DB00396, DB00421, DB00588, DB00687, DB00700, DB01395 Y
Myc proto-oncogene protein MYC P01106 DB08813 N
Nuclear factor NF-kappa-B p100 subunit NFKB2 Q00653 DB01296 N
Nuclear factor NF-kappa-B p105 subunit NFKB1 P19838 DB01041, DB01411, DB08814 N
Nuclear receptor ROR-beta RORB Q92753 DB01065 N
Nuclear receptor subfamily 0 group B member 1 NR0B1 P51843 DB00755, DB01234 N
Nuclear receptor subfamily 1 group I member 2 NR1I2 O75469 DB00163, DB00530, DB00783, DB00977, DB01045, DB01220, DB01229, DB08864 Y
Peroxisome proliferator-activated receptor alpha PPARA Q07869 DB00636, DB01039, DB01241, DB01393 Y
Peroxisome proliferator-activated receptor delta PPARD Q03181 DB00159, DB00374, DB00605, DB01393 Y
Peroxisome proliferator-activated receptor gamma PPARG P37231 DB00159, DB00244, DB00328, DB00412, DB00731, DB00795, DB00912, DB00966, DB01014, DB01050, DB01067, DB01132, DB01252, DB01393 Y
Progesterone receptor PGR P06401 DB00294, DB00304, DB00351, DB00367, DB00378, DB00396, DB00588, DB00603, DB00717, DB00823, DB00834, DB00957, DB01395, DB01406, DB01431, DB06713 Y
Proto-oncogene c-Fos FOS P01100 DB08813 N
Retinoic acid receptor RXR-alpha RXRA P19793 DB00210, DB00307, DB00459, DB00523, DB00749 Y
Retinoic acid receptor RXR-beta RXRB P28702 DB00210, DB00307, DB00459, DB00523, DB00755, DB00799 Y
Retinoic acid receptor RXR-gamma RXRG P48443 DB00210, DB00307, DB00459, DB00523, DB00755 N
Retinoic acid receptor alpha RARA P10276 DB00210, DB00459, DB00523, DB00799, DB00982, DB04942 Y
Retinoic acid receptor beta RARB P10826 DB00210, DB00459, DB00523, DB00799, DB04942 Y
Retinoic acid receptor gamma RARG P13631 DB00210, DB00459, DB00523, DB00755, DB00799 Y
Signal transducer and activator of transcription 5B STAT5B P51692 DB01254 N
Thyroid hormone receptor alpha THRA P10827 DB00279, DB00451, DB00509, DB01583 Y
Thyroid hormone receptor beta THRB P10828 DB00279, DB00451, DB00509, DB01583 Y
Transcription factor AP-1 JUN P05412 DB00570, DB01029, DB01169 N
Vitamin D3 receptor VDR P11473 DB00136, DB00146, DB00153, DB00169, DB00910, DB01070, DB01436, DB02300 Y