The table lists druggable TFs and approved drugs, which are extracted from the DrugBank database. 20 out of 32 druggable TFs are available in the SM-TF database.
TF name |
Gene |
UniProt |
Drugs [DrugBank] |
SM-TF |
Androgen receptor |
AR |
P10275 |
DB00367, DB00421, DB00499, DB00621, DB00624, DB00665, DB00687, DB00858, DB00984, DB01128, DB01185, DB01395, DB01406, DB01420, DB04839, DB06710, DB08804, DB08899 |
Y |
Aryl hydrocarbon receptor |
AHR |
P35869 |
DB00379, DB00499, DB01076, DB01097, DB01404 |
N |
Bile acid receptor |
NR1H4 |
Q96RI1 |
DB06777 |
Y |
Cyclic AMP-responsive element-binding protein 1 |
CREB1 |
P16220 |
DB00131, DB01183 |
N |
DNA (cytosine-5)-methyltransferase 1 |
DNMT1 |
P26358 |
DB00928, DB01035, DB01099, DB01262 |
N |
Estrogen receptor |
ESR1 |
P03372 |
DB00255, DB00269, DB00286, DB00294, DB00304, DB00367, DB00396, DB00481, DB00539, DB00603, DB00655, DB00675, DB00783, DB00823, DB00882, DB00890, DB00947, DB00957, DB00977, DB01065, DB01108, DB01183, DB01185, DB01196, DB01357, DB01406, DB01431, DB04573, DB04574, DB04575, DB04938 |
Y |
Estrogen receptor beta |
ESR2 |
Q92731 |
DB00255, DB00481, DB00675, DB00783, DB01108, DB01196, DB04573, DB04574 |
Y |
Estrogen-related receptor gamma |
ESRRG |
P62508 |
DB00255 |
Y |
Glucocorticoid receptor |
NR3C1 |
P04150 |
DB00180, DB00223, DB00240, DB00253, DB00288, DB00324, DB00351, DB00394, DB00443, DB00547, DB00588, DB00591, DB00596, DB00620, DB00635, DB00663, DB00687, DB00741, DB00764, DB00769, DB00834, DB00838, DB00846, DB00860, DB00873, DB00896, DB00959, DB01013, DB01047, DB01130, DB01185, DB01222, DB01234, DB01260, DB01380, DB01384, DB01410, DB06781, DB08906 |
Y |
Mineralocorticoid receptor |
NR3C2 |
P08235 |
DB00393, DB00396, DB00421, DB00588, DB00687, DB00700, DB01395 |
Y |
Myc proto-oncogene protein |
MYC |
P01106 |
DB08813 |
N |
Nuclear factor NF-kappa-B p100 subunit |
NFKB2 |
Q00653 |
DB01296 |
N |
Nuclear factor NF-kappa-B p105 subunit |
NFKB1 |
P19838 |
DB01041, DB01411, DB08814 |
N |
Nuclear receptor ROR-beta |
RORB |
Q92753 |
DB01065 |
N |
Nuclear receptor subfamily 0 group B member 1 |
NR0B1 |
P51843 |
DB00755, DB01234 |
N |
Nuclear receptor subfamily 1 group I member 2 |
NR1I2 |
O75469 |
DB00163, DB00530, DB00783, DB00977, DB01045, DB01220, DB01229, DB08864 |
Y |
Peroxisome proliferator-activated receptor alpha |
PPARA |
Q07869 |
DB00636, DB01039, DB01241, DB01393 |
Y |
Peroxisome proliferator-activated receptor delta |
PPARD |
Q03181 |
DB00159, DB00374, DB00605, DB01393 |
Y |
Peroxisome proliferator-activated receptor gamma |
PPARG |
P37231 |
DB00159, DB00244, DB00328, DB00412, DB00731, DB00795, DB00912, DB00966, DB01014, DB01050, DB01067, DB01132, DB01252, DB01393 |
Y |
Progesterone receptor |
PGR |
P06401 |
DB00294, DB00304, DB00351, DB00367, DB00378, DB00396, DB00588, DB00603, DB00717, DB00823, DB00834, DB00957, DB01395, DB01406, DB01431, DB06713 |
Y |
Proto-oncogene c-Fos |
FOS |
P01100 |
DB08813 |
N |
Retinoic acid receptor RXR-alpha |
RXRA |
P19793 |
DB00210, DB00307, DB00459, DB00523, DB00749 |
Y |
Retinoic acid receptor RXR-beta |
RXRB |
P28702 |
DB00210, DB00307, DB00459, DB00523, DB00755, DB00799 |
Y |
Retinoic acid receptor RXR-gamma |
RXRG |
P48443 |
DB00210, DB00307, DB00459, DB00523, DB00755 |
N |
Retinoic acid receptor alpha |
RARA |
P10276 |
DB00210, DB00459, DB00523, DB00799, DB00982, DB04942 |
Y |
Retinoic acid receptor beta |
RARB |
P10826 |
DB00210, DB00459, DB00523, DB00799, DB04942 |
Y |
Retinoic acid receptor gamma |
RARG |
P13631 |
DB00210, DB00459, DB00523, DB00755, DB00799 |
Y |
Signal transducer and activator of transcription 5B |
STAT5B |
P51692 |
DB01254 |
N |
Thyroid hormone receptor alpha |
THRA |
P10827 |
DB00279, DB00451, DB00509, DB01583 |
Y |
Thyroid hormone receptor beta |
THRB |
P10828 |
DB00279, DB00451, DB00509, DB01583 |
Y |
Transcription factor AP-1 |
JUN |
P05412 |
DB00570, DB01029, DB01169 |
N |
Vitamin D3 receptor |
VDR |
P11473 |
DB00136, DB00146, DB00153, DB00169, DB00910, DB01070, DB01436, DB02300 |
Y |