SM-TF Data
"Organism", "Protein", and "Gene" of TFs are taken from the UniProt database.
TFs from human and mouse are linked to the TFClass database.
TFs from E. coli are linked to the RegulonDB.
20 out of 32 Druggable TFs (marked by DT in the "UniProt" column), extracted from the DrugBank database, are available in the SM-TF database. A table containing all the Druggable TFs and their corresponding approved drugs is provided HERE.
UniProt | Organism | Protein | Gene | Small Molecules | PDBs | TFClass / RegulonDB |
SM-TF |
---|---|---|---|---|---|---|---|
Q99814 | Homo sapiens | Endothelial PAS domain-containing protein 1 | EPAS1 | 2XY, 018, 020, 0X3, 0XB | 3F1O, 3H7W, 3H82, 4GHI, 4GS9 | 1.2.5.1.7 | link |
DTP04150 | Homo sapiens | Glucocorticoid receptor | NR3C1 | DEX, 486, DAY, GW6, 866, JZR, JZS, JZN, NN7, LSJ, 29M, MOF, HCY | 1M2Z, 1NHZ, 3BQD, 3CLD, 3E7C, 3K22, 3K23, 4CSJ, 4LSJ, 4MDD, 4P6W, 4P6X | 2.1.1.1.1 | link |
DTP08235 | Homo sapiens | Mineralocorticoid receptor | NR3C2 | 1CA, C0R, AS4, STR, PDN, SNL, LD1, LD2, WFF, WFG, HFN | 1Y9R, 2A3I, 2AA2, 2AA6, 2AAX, 2AB2, 3VHV, 3WFF, 3WFG, 4PF3 | 2.1.1.1.2 | link |
DTP06401 | Homo sapiens | Progesterone receptor | PGR | STR, R18, NDR, MOF, T98, AS0, 486, NOG, 30X, GKK, WOW, OR8, ORB, ORC, A2K, 2S0 | 1A28, 1E3K, 1SQN, 1SR7, 1ZUC, 2OVH, 2OVM, 2W8Y, 3D90, 3G8O, 3HQ5, 3KBA, 3ZR7, 3ZRA, 3ZRB, 4A2J, 4APU, 4OAR | 2.1.1.1.3 | link |
DTP10275 | Homo sapiens | Androgen receptor | AR | ZK5, R18, 198, TES, 17H, FHM, BHM, LGD, CA4, 2MI, ICO, K10, RB1, NK, 4HY, T3, FLF, ENM, YLO, 056, YLQ, B5R, 3B6, B66, B67, B68, RLJ, RLL, PK0, PK1, 30Z, 17W, MXD, HFT | 1GS4, 1XOW, 1Z95, 2AM9, 2AMB, 2AX8, 2AX9, 2HVC, 2OZ7, 2PIO, 2PIP, 2PIQ, 2PIR, 2PIT, 2PIV, 2PIX, 2PNU, 2YLO, 2YLP, 2YLQ, 3B5R, 3B65, 3B66, 3B67, 3B68, 3L3X, 3RLJ, 3RLL, 3V49, 3V4A, 3ZQT, 4HLW, 4K7A, 4OHA | 2.1.1.1.4 | link |
DTP03372 | Homo sapiens | Estrogen receptor | ESR1 | ZTW, ETC, GW5, E4D, PTI, 244, AIH, AIU, AIJ, AIT, AEJ, CM4, CM3, 689, L4G, 458, 17M, 459, T3O, DRQ, I0G, IOG, IOK, C3D, EZT, WST, A48, DC8, KN2, GEN, EI1, JJ3, EED, EES, ODE, HZ3, 1HP, PIQ, RAL, KN1, LLB, LLC, EEU, MLZ, SFG, 369, DES, OHT, J2Z, J3Z, 4OH, KN0, ESL, Q97, SRR, 2OH, 0CZ, 0D1, EST, 0L8, 1GM, 1GQ, 1GR, 1GS, 1GJ, 1GT, 1GU, KN3, 1GV, 15Q, TPO, 27E, 27G, 27H, 27J, 27K, 27L, XDH, 27M, 27N, STL, FSV, ESE | 1GWQ, 1L2I, 1R5K, 1SJ0, 1UOM, 1X7E, 1XP1, 1XP6, 1XP9, 1XPC, 1XQC, 1YIM, 1YIN, 1ZKY, 2AYR, 2B1V, 2B1Z, 2FAI, 2G44, 2G5O, 2I0J, 2IOG, 2IOK, 2OUZ, 2P15, 2POG, 2Q6J, 2Q70, 2QA6, 2QA8, 2QAB, 2QE4, 2QGT, 2QGW, 2QH6, 2QR9, 2QSE, 2QXM, 2QXS, 2QZO, 2R6W, 2R6Y, 2YAT, 3CBO, 3CBP, 3DT3, 3ERD, 3ERT, 3HLV, 3HM1, 3L03, 3OS8, 3Q95, 3Q97, 3UU7, 3UUA, 3UUC, 3UUD, 4DMA, 4IU7, 4IUI, 4IV2, 4IV4, 4IVW, 4IVY, 4IW6, 4IW8, 4IWC, 4IWF, 4JC3, 4MG5, 4MG6, 4MG7, 4MG8, 4MG9, 4MGA, 4MGB, 4MGC, 4MGD, 4PP6, 4PPP, 4PPS | 2.1.1.2.1 | link |
DTQ92731 | Homo sapiens | Estrogen receptor beta | ESR2 | ETC, MON, GEN, 272, 338, 797, 397, 697, 244, 041, 4NA, 196, 789, OHT, FBR, I0G, JJ3, 555, 3AS, YJD, SU4, DC8, EST, WV7, W14, W23 | 1L2J, 1NDE, 1QKM, 1U3Q, 1U3R, 1U3S, 1U9E, 1X76, 1X78, 1X7B, 1YY4, 1YYE, 1ZAF, 2FSZ, 2GIU, 2I0G, 2JJ3, 2NV7, 2QTU, 2YJD, 2YLY, 2Z4B, 3OLL, 3OMO, 3OMP, 3OMQ | 2.1.1.2.2 | link |
P11474 | Homo sapiens | Steroid hormone receptor ERR1 | ESRRA | 047, 5FB | 2PJL, 3K6P | 2.1.1.2.3 | link |
DTP62508 | Homo sapiens | Estrogen-related receptor gamma | ESRRG | 2OH, TXF, 1BA, OHT, 43M, 1OH, BPZ | 2E2R, 2EWP, 2GPP, 2GPU, 2P7A, 2ZAS, 2ZKC | 2.1.1.2.5 | link |
DTP10276 | Homo sapiens | Retinoic acid receptor alpha | RARA | BMS, REA, EQN, EQO, LUF | 1DKF, 3A9E, 3KMR, 3KMZ, 4DQM | 2.1.2.1.1 | link |
DTP10826 | Homo sapiens | Retinoic acid receptor beta | RARB | TTB, REA, 1NY, JYH, JYI | 4DM6, 4DM8, 4JYG, 4JYH, 4JYI | 2.1.2.1.2 | link |
DTP13631 | Homo sapiens | Retinoic acid receptor gamma | RARG | 394, 961, 184, 564, LMU, 156, 254, REA | 1EXA, 1EXX, 1FCX, 1FCY, 1FCZ, 1FD0, 2LBD | 2.1.2.1.3 | link |
DTP10827 | Homo sapiens | Thyroid hormone receptor alpha | THRA | IH5, T3, B72, 4HY | 1NAV, 2H79, 3ILZ, 3JZB, 4LNX | 2.1.2.2.1 | link |
DTP10828 | Homo sapiens | Thyroid hormone receptor beta | THRB | PFA, IH5, G24, 442, T44, OEF, LEG, 4HY, T3, B72 | 1N46, 1NAX, 1Q4X, 1R6G, 1Y0X, 2J4A, 2PIN, 3D57, 3GWS, 3IMY | 2.1.2.2.2 | link |
Q14995 | Homo sapiens | Nuclear receptor subfamily 1 group D member 2 | NR1D2 | HEM, COH | 3CQV, 4N73 | 2.1.2.3.2 | link |
DTP11473 | Homo sapiens | Vitamin D3 receptor | VDR | KH1, VDX, EB1, MC9, TX5, C33, OCC, C3O, O1C, MVD, TEJ, 2MV, 23R, 3EV, CA9, EIM, DS2, DS3, DS6, MCZ, COV, 0CO, ZNE, FMV, ZYD, VHW, DS5, 6DS, DS4, ED9, 0VQ, TEY, TFY | 1IE8, 1IE9, 1S0Z, 1S19, 1TXI, 2HAM, 2HAR, 2HAS, 2HB7, 2HB8, 3A2J, 3A3Z, 3A40, 3A78, 3AUR, 3AX8, 3AZ1, 3AZ2, 3AZ3, 3B0T, 3CS4, 3CS6, 3KPZ, 3OGT, 3P8X, 3VHW, 3W0A, 3W0C, 3W0Y, 3WGP, 4G2I, 4ITE, 4ITF | 2.1.2.4.1 | link |
DTO75469 | Homo sapiens | Nuclear receptor subfamily 1 group I member 2 | NR1I2 | HYF, SRL, RFP, 444, CDZ, PNU, 2Q4 | 1M13, 1NRL, 1SKX, 2O9I, 2QNV, 3R8D, 4NY9 | 2.1.2.4.2 | link |
Q14994 | Homo sapiens | Nuclear receptor subfamily 1 group I member 3 | NR1I3 | CI2, CID | 1XV9, 1XVP | 2.1.2.4.3 | link |
DTQ07869 | Homo sapiens | Peroxisome proliferator-activated receptor alpha | PPARA | AZ2, CPQ, 544, 471, MMB, 735, REW, S44, ET1, CTM, RO7, 7HA, NKS, IL2, 13M, WY1 | 1I7G, 1K7L, 1KKQ, 2NPA, 2P54, 2REW, 2ZNN, 3ET1, 3FEI, 3G8I, 3KDT, 3KDU, 3SP6, 3VI8, 4BCR | 2.1.2.5.1 | link |
DTQ03181 | Homo sapiens | Peroxisome proliferator-activated receptor delta | PPARD | 433, 331, B7G, VCA, GNI, 1FA, WLM, 08S, BOG, Z00, K55, 401, L41, DY6, ET1, EPA, D32, 3OZ, 3EQ, JZR, IL2, GW0 | 1GWX, 1Y0S, 2AWH, 2J14, 2Q5G, 2XYJ, 2XYW, 2XYX, 2ZNP, 2ZNQ, 3D5F, 3DY6, 3ET2, 3GWX, 3GZ9, 3OZ0, 3PEQ, 3SP9, 3TKM | 2.1.2.5.2 | link |
DTP37231 | Homo sapiens | Peroxisome proliferator-activated receptor gamma | PPARG | 570, AZ2, 544, YPA, DRF, C01, BRL, 3EA, EHA, RO0, SP0, SP3, 208, NSI, DRY, DRD, DRJ, DRH, AJA, C03, GW4, 240, 241, NZA, SF1, SF2, PLB, L92, 9HO, 243, HXA, 4HD, 5HE, 4R8, 6OB, 6OC, P1B, YFE, GSH, PTG, OCX, C08, S44, HID, SRO, MYI, OCR, IMN, NRO, M7S, M7R, MC5, GW9, KRC, ZAA, YRG, GRR, LNA, LNB, ET0, ET1, CTM, Z12, RO7, 2PQ, D30, DKD, ZZH, UNT, Z27, 538, CEK, 5BC, XDH, XDI, ZXG, XPT, 486, MLO, HIG, XCX, M0T, LU2, MYR, 3T0, 082, DKA, 17L, 21L, 24L, J35, J53, TLS, EK1, EK8, TBY, T9T, JJA, YFD, YFB, RRG, RRH, KNA, FCM, 0W3, 14R, STL, AXY, LRG, 072 | 1FM9, 1I7I, 1K74, 1KNU, 1NYX, 1ZEO, 1ZGY, 2ATH, 2F4B, 2FVJ, 2G0G, 2G0H, 2GTK, 2HFP, 2HWQ, 2HWR, 2I4J, 2I4P, 2OM9, 2P4Y, 2POB, 2Q59, 2Q5P, 2Q5S, 2Q61, 2Q6R, 2Q6S, 2Q8S, 2VSR, 2VST, 2VV0, 2VV1, 2VV2, 2VV3, 2VV4, 2XKW, 2YFE, 2ZK2, 2ZK3, 2ZK6, 2ZNO, 2ZVT, 3ADT, 3ADV, 3ADW, 3ADX, 3AN3, 3AN4, 3B0Q, 3B0R, 3B1M, 3BC5, 3CDP, 3CDS, 3CWD, 3ET0, 3ET3, 3FEJ, 3FUR, 3G9E, 3GBK, 3H0A, 3HO0, 3HOD, 3IA6, 3K8S, 3KMG, 3LMP, 3NOA, 3OSI, 3OSW, 3PBA, 3PO9, 3QT0, 3R5N, 3R8A, 3R8I, 3S9S, 3SZ1, 3T03, 3TY0, 3U9Q, 3V9T, 3V9V, 3V9Y, 3VJH, 3VJI, 3VN2, 3VSO, 3VSP, 3WJ4, 3WJ5, 3WMH, 4A4V, 4A4W, 4E4K, 4E4Q, 4EM9, 4F9M, 4FGY, 4HEE, 4JAZ, 4JL4, 4L98, 4PRG | 2.1.2.5.3 | link |
P35398 | Homo sapiens | Nuclear receptor ROR-alpha | RORA | CLR, C3S | 1N83, 1S0X | 2.1.2.6.1 | link |
P51449 | Homo sapiens | Nuclear receptor ROR-gamma | RORC | DGX, HC2, HC9, HC3, 444, NBH, 39K, 3QQ | 3B0W, 3KYT, 3L0J, 3L0L, 4NB6, 4NIE, 4QM0, 4WLB | 2.1.2.6.3 | link |
Q13133 | Homo sapiens | Oxysterols receptor LXR-alpha | NR1H3 | 444, 965, O90, O40 | 1UHL, 3IPQ, 3IPS, 3IPU | 2.1.2.7.1 | link |
P55055 | Homo sapiens | Oxysterols receptor LXR-beta | NR1H2 | CO1, 965, 44B, 444, 61X, G58, 0KS, 0KT | 1P8D, 1PQ6, 1PQ9, 1UPV, 3KFC, 3L0E, 4DK7, 4DK8 | 2.1.2.7.2 | link |
DTQ96RI1 | Homo sapiens | Bile acid receptor | NR1H4 | FEX, MUF, 064, O62, 33Y, 643, 708, 82X, 088, 635, OKH, OKI, OLF, OMK, OMM, OOF, OOK, P88, 89P, 59G, 37G, 034, IVM | 1OSH, 3BEJ, 3DCT, 3DCU, 3FLI, 3FXV, 3GD2, 3HC5, 3HC6, 3L1B, 3OKH, 3OKI, 3OLF, 3OMK, 3OMM, 3OOF, 3OOK, 3P88, 3P89, 3RUT, 3RUU, 3RVF, 4WVD | 2.1.2.7.3 | link |
DTP19793 | Homo sapiens | Retinoic acid receptor RXR-alpha | RXRA | 9CR, REA, HXA, BM6, L79, F15, 3TN, 4TN, 5TN, P26, 21P, TBY, 2E3, 9RA, T9T, CHZ, BGV, LX8, RHN, MLO, 1O8, 29V, R4M, K09, K08, 2QO, 2VR, 2VP, 2VZ, 2W0 | 1FM6, 1G5Y, 1MV9, 1MVC, 1RDT, 1XVP, 2P1T, 2P1U, 2P1V, 2ZXZ, 2ZY0, 3E94, 3FUG, 3H0A, 3KWY, 3NSQ, 3OZJ, 3PCU, 3R2A, 3R5M, 4K4J, 4M8E, 4M8H, 4N5G, 4N8R, 4OC7, 4POH, 4POJ, 4PP3, 4PP5 | 2.1.3.1.1 | link |
DTP28702 | Homo sapiens | Retinoic acid receptor RXR-beta | RXRB | LG2, MEI | 1H9U, 1UHL | 2.1.3.1.2 | link |
P41235 | Homo sapiens | Hepatocyte nuclear factor 4-alpha | HNF4A | MYR | 1PZL | 2.1.3.2.1 | link |
Q14541 | Homo sapiens | Hepatocyte nuclear factor 4-gamma | HNF4G | PLM | 1LV2 | 2.1.3.2.2 | link |
Q9Y466 | Homo sapiens | Nuclear receptor subfamily 2 group E member 1 | NR2E1 | MAL | 4XAJ | 2.1.3.3.1 | link |
P22736 | Homo sapiens | Nuclear receptor subfamily 4 group A member 1 | NR4A1 | TMY, T94, ZJ0 | 3V3Q, 4JGV, 4KZI | 2.1.4.0.1 | link |
Q13285 | Homo sapiens | Steroidogenic factor 1 | NR5A1 | P0E, PEF, PIZ, PIK | 1YOW, 1ZDT, 4QJR, 4QK4 | 2.1.5.0.1 | link |
O00482 | Homo sapiens | Nuclear receptor subfamily 5 group A member 2 | NR5A2 | P6L, EPH, P3A, 470, PLC | 1YOK, 1YUC, 1ZDU, 3PLZ, 4DOS | 2.1.5.0.2 | link |
P41182 | Homo sapiens | B-cell lymphoma 6 protein | BCL6 | Z88, Z89, RBT | 3LBZ, 4CP3 | 2.3.3.22.2 | link |
Q03164 | Homo sapiens | Histone-lysine N-methyltransferase 2A | KMT2A | SAH | 2W5Y | 2.6.1.0.4 | link |
Q92794 | Homo sapiens | Histone acetyltransferase KAT6A | KAT6A | ACO | 2OZU | 2.7.3.0.3 | link |
Q9Y468 | Homo sapiens | Lethal(3)malignant brain tumor-like protein 1 | L3MBTL1 | MES, MLY, MLZ, P8H, UWN | 1OYX, 1OZ2, 2RHU, 2RHY, 3P8H, 3UWN | 2.7.4.0.1 | link |
Q15475 | Homo sapiens | Homeobox protein SIX1 | SIX1 | MAL | 4EGC | 3.1.6.1.1 | link |
O75376 | Homo sapiens | Nuclear receptor corepressor 1 | NCOR1 | 486 | 3H52 | 3.5.1.2.1 | link |
Q02078 | Homo sapiens | Myocyte-specific enhancer factor 2A | MEF2A | BXL | 3MU6 | 5.1.1.1.1 | link |
P04637 | Homo sapiens | Cellular tumor antigen p53 | TP53 | P83, X0U, X0V, X0W, QC5, P84, P86, NXG, P74, P51, P96 | 2VUK, 2X0U, 2X0V, 2X0W, 3ZME, 4AGL, 4AGM, 4AGN, 4AGO, 4AGP, 4AGQ | 6.3.1.0.1 | link |
O00255 | Homo sapiens | Menin | MEN1 | 0BR, CHD, 0RO, 0RT, 2S6, 2VK, 2S7, 2S9, 2SE, 2SF, 3XW, 3XY | 3U88, 4GQ3, 4GQ4, 4OG3, 4OG4, 4OG5, 4OG6, 4OG7, 4OG8, 4X5Y, 4X5Z | N/A | link |
O15164 | Homo sapiens | Transcription intermediary factor 1-alpha | TRIM24 | ALY | 3O36 | N/A | link |
O60341 | Homo sapiens | Lysine-specific histone demethylase 1A | KDM1A | FAD, FAD-TCF, FAD-3PL, FAD-TCA, FAD-M84, M80, F2N, FAJ, 2PF, 12F, THG, D69, D70, D73, D51, D52, FAD-M8A | 2DW4, 2XAG, 2XAH, 2XAJ, 2XAQ, 2XAS, 2Z3Y, 2Z5U, 3ABT, 3ABU, 4KUM, 4UV8, 4UV9, 4UVA, 4UVB, 4UVC, 4UXN | N/A | link |
P22392 | Homo sapiens | Nucleoside diphosphate kinase B | NME2 | DA-DG, DG, GDP | 3BBB, 3BBF | N/A | link |
P51532 | Homo sapiens | Transcription activator BRG1 | SMARCA4 | MB3 | 3UVD | N/A | link |
Q13363 | Homo sapiens | C-terminal-binding protein 1 | CTBP1 | NAD, KMT, 3CR, NAI, PPY | 1MX3, 4LCE, 4U6Q, 4U6S | N/A | link |
Q92793 | Homo sapiens | CREB-binding protein | CREBBP | ALY, MB3, DMS, 3PF, KRG, TYL, 2LK, 2LL, 2LN, 2LO, 15E, 2O3, 2O4 | 3P1C, 3P1D, 3P1E, 3P1F, 3SVH, 4A9K, 4NR4, 4NR5, 4NR6, 4NR7, 4NYV, 4NYW, 4NYX | N/A | link |
Q96T88 | Homo sapiens | E3 ubiquitin-protein ligase UHRF1 | UHRF1 | 36X | 4QQD | N/A | link |
Q9NRY4 | Homo sapiens | Rho GTPase-activating protein 35 | ARHGAP35 | GNP | 3C5H | N/A | link |
Q9UQR0 | Homo sapiens | Sex comb on midleg-like protein 2 | SCML2 | MLZ | 2VYT | N/A | link |
P03023 | Escherichia coli | Lactose operon repressor | lacI | NPF, IPT, 145, HEZ | 1EFA, 2P9H, 2PE5, 3EDC | ECK120012762 | link |
P07026 | Escherichia coli | Regulatory protein SdiA | sdiA | HTF | 2AVX | ECK120011856 | link |
P09546 | Escherichia coli | Bifunctional protein PutA | putA | 2OP, SO2, PRO, FAD, HYP, TFB | 1TJ1, 2FZM, 2FZN, 3E2Q, 3E2R | ECK120012029 | link |
P0A6D0 | Escherichia coli | Arginine repressor | argR | ARG | 1XXA | ECK120011670 | link |
P0A6Z6 | Escherichia coli | Nickel-responsive regulator | nikR | 3CM | 2HZA | ECK120023539 | link |
P0A881 | Escherichia coli | Trp operon repressor | trpR | TRP | 1JHG | ECK120012176 | link |
P0A8U6 | Escherichia coli | Met repressor | metJ | SAM | 1CMC | ECK120048948 | link |
P0A9E0 | Escherichia coli | Arabinose operon regulatory protein | araC | FCB, ARA | 2AAC, 2ARC | ECK120012316 | link |
P0ACI3 | Escherichia coli | Xylose operon regulatory protein | xylR | XYS | 4FE7 | ECK120013786 | link |
P0ACI6 | Escherichia coli | Regulatory protein AsnC | asnC | ASN | 2CG4 | ECK120013010 | link |
P0ACJ8 | Escherichia coli | cAMP-activated global transcriptional regulator CRP | crp | CMP | 4HZF | ECK120011235 | link |
P0ACP7 | Escherichia coli | HTH-type transcriptional repressor PurR | purR | HPA, GUN, 6MP, ADE | 1JFT, 1WET, 2PUA, 2PUB | ECK120012854 | link |
P0ACU2 | Escherichia coli | HTH-type transcriptional regulator RutR | rutR | URA | 4JYK | ECK120033905 | link |
P16528 | Escherichia coli | Acetate operon repressor | iclR | GOA, PYR | 2O99, 2O9A | ECK120011897 | link |
P24242 | Escherichia coli | HTH-type transcriptional regulator AscG | ascG | FRU | 3BRQ | ECK120026318 | link |
P27111 | Escherichia coli | HTH-type transcriptional regulator CynR | cynR | AZI | 3HFU | ECK120013065 | link |
P27245 | Escherichia coli | Multiple antibiotic resistance protein MarR | marR | SAL | 1JGS | ECK120013191 | link |
P37344 | Escherichia coli | Psp operon transcriptional activator | pspF | ANP, AMP, ATP, ADP | 2C99, 2VII, 4QNR, 4QOS | ECK120011400 | link |
P76016 | Escherichia coli | PTS-dependent dihydroxyacetone kinase operon regulatory protein | dhaR | ADP | 4LRZ | ECK120015690 | link |
P0A8V6 | Escherichia coli O157:H7. | Fatty acid metabolism regulator protein | fadR | COA-MYR | 1H9G | ECK120011824 | link |
Q8XBD0 | Escherichia coli O157:H7. | Transcriptional regulator of ftsQAZ gene cluster | sdiA | 480, 482, LAE | 4Y13, 4Y15, 4Y17 | ECK120011856 | link |
P06537 | Mus musculus | Glucocorticoid receptor | Nr3c1 | DEX | 3MNP | 2.1.1.1.1 | link |
P19091 | Mus musculus | Androgen receptor | Ar | 4HY, DHT | 2QPY | 2.1.1.1.4 | link |
P62509 | Mus musculus | Estrogen-related receptor gamma | Esrrg | DES, CHD, OHT | 1S9P, 1S9Q | 2.1.1.2.5 | link |
P22605 | Mus musculus | Retinoic acid receptor beta | Rarb | REA | 1XDK | 2.1.2.1.2 | link |
O35627 | Mus musculus | Nuclear receptor subfamily 1 group I member 3 | Nr1i3 | TCD, ATE | 1XLS, 1XNX | 2.1.2.4.3 | link |
Q9Z0Y9 | Mus musculus | Oxysterols receptor LXR-alpha | Nr1h3 | L05, LO2, LX2 | 2ACL, 3FAL, 3FC6 | 2.1.2.7.1 | link |
P28700 | Mus musculus | Retinoic acid receptor RXR-alpha | Rxra | OLA, REA, 754 | 1DKF, 1XDK, 3A9E | 2.1.3.1.1 | link |
P33242 | Mus musculus | Steroidogenic factor 1 | Nr5a1 | DR9, PEF, P42 | 1YMT, 1YP0, 3F7D | 2.1.5.0.1 | link |
Q62227 | Mus musculus | Nuclear receptor subfamily 0 group B member 2 | Nr0b2 | MAL | 4NUF | 2.1.7.0.2 | link |
Q96EQ9 | Mus musculus | Histone-lysine N-methyltransferase PRDM9 | Prdm9 | SAH | 4C1Q | 2.3.4.0.71 | link |
P02340 | Mus musculus | Cellular tumor antigen p53 | Tp53 | TRS, FLC | 2IOI, 3EXJ | 6.3.1.0.1 | link |
O05521 | Bacillus subtilis | Redox-sensing transcriptional repressor Rex | rex | NAD, ATP | 2VT2, 2VT3 | N/A | link |
O34835 | Bacillus subtilis | Transcription factor FapR | fapR | MLC | 2F3X | N/A | link |
O34994 | Bacillus subtilis | Transcriptional repressor CcpN | ccpN | ADP, ANP | 3FWR, 3FWS | N/A | link |
P11065 | Bacillus subtilis | HTH-type transcriptional regulator Hpr | hpr | 1PE, P6G, PGE | 2FXA | N/A | link |
P17893 | Bacillus subtilis | Arginine repressor | argR | ARG | 2P5M | N/A | link |
P39779 | Bacillus subtilis | GTP-sensing transcriptional pleiotropic repressor CodY | codY | ILE, VAL | 2B18, 2HGV | N/A | link |
P94426 | Bacillus subtilis | HTH-type transcriptional regulatory protein GabR | gabR | LLP | 4N0B | N/A | link |
P96711 | Bacillus subtilis | Arabinose metabolism transcriptional repressor | araR | ARB | 3TB6 | N/A | link |
P13053 | Rattus norvegicus | Vitamin D3 receptor | Vdr | VDZ, VD1, VD2, VD4, VD5, YR3, VDA, VDB, NYA, TT2, MI4, JB1, JC1, TEJ, ICJ, YR4, 10S, 10R, YS2, YS3, YSD, YS5, 5YI, YI2, VDX, YI3, YI4, TKA, TK3, TKD, W07, W12, O11, T08, 4OA, 3KL, LOA, LHP, YA1, YA2 | 1RJK, 1RKG, 1RKH, 2O4J, 2O4R, 2ZFX, 2ZL9, 2ZLA, 2ZMH, 2ZMI, 2ZMJ, 2ZXM, 2ZXN, 3A2H, 3AFR, 3AUN, 3VJS, 3VJT, 3VRT, 3VRU, 3VRV, 3VRW, 3VT4, 3VT5, 3VT7, 3VT8, 3VT9, 3VTB, 3VTC, 3VTD, 3W0G, 3W0H, 3W0I, 3W0J, 3W5P, 3W5Q, 3W5R, 3W5T, 3WT5, 3WT7 | N/A | link |
P15207 | Rattus norvegicus | Androgen receptor | Ar | DHT, HYQ, LG7, 8NH, LGB | 1I37, 1XNN, 2IHQ, 2NW4, 3G0W | N/A | link |
P22449 | Rattus norvegicus | Hepatocyte nuclear factor 4-alpha | Hnf4a | DAO | 1M7W | N/A | link |
P45446 | Rattus norvegicus | Nuclear receptor ROR-beta | Rorb | STE, REA, ARL | 1K4W, 1N4H, 1NQ7 | N/A | link |
Q62735 | Rattus norvegicus | Bile acid receptor | Nr1h4 | CHC, IU5 | 1OSV, 1OT7 | N/A | link |
Q62986 | Rattus norvegicus | Estrogen receptor beta | Esr2 | AOE, RAL, EST, E3O | 1HJ1, 1QKN, 2J7X, 2J7Y | N/A | link |
Q9Z2F5 | Rattus norvegicus | C-terminal-binding protein 1 | Ctbp1 | NAD | 1HKU | N/A | link |
O68014 | Acinetobacter baylyi | HTH-type transcriptional regulator BenM | benM | BEZ, CCU | 2F78, 2F7A | N/A | link |
P07774 | Acinetobacter baylyi | HTH-type transcriptional regulator CatM | catM | CCU | 2F7C | N/A | link |
Q7X0D9 | Acinetobacter baylyi | HcaR protein | hcaR | HC4, V55, FER, DHB | 4RGR, 4RGS, 4RGU, 4RGX | N/A | link |
A9CIH8 | Agrobacterium tumefaciens | Transcriptional regulator, AsnC family | Atu1885 | ACT | 3I4P | N/A | link |
A6TKU5 | Alkaliphilus metalliredigens | Periplasmic binding protein/LacI transcriptional regulator | Amet_0586 | XLF | 3CTP | N/A | link |
O67198 | Aquifex aeolicus | Transcriptional regulator (NtrC family) | ntrC1 | ADP, ATP, 08T | 1NY5, 3M0E, 4LZZ | N/A | link |
A0K1X3 | Arthrobacter sp. | Transcriptional regulator, LacI family | Arth_3918 | LBT | 4RKR | N/A | link |
P46828 | Bacillus megaterium. | Catabolite control protein A | ccpA | BG6, FBP | 2NZU, 2NZV | N/A | link |
Q3AB29 | Carboxydothermus hydrogenoformans | Carbon monoxide oxidation system transcription regulator | cooA-1 | HEM | 2FMY | N/A | link |
A9WGF5 | Chloroflexus aurantiacus | Helix-turn-helix domain protein | Caur_2278 | MYR | 3PXP | N/A | link |
Q7NQP7 | Chromobacterium violaceum | Transcriptional activator, LuxR/UhpA family of regulators | cviR | HL6, HL0 | 3QP6, 3QP8 | N/A | link |
D3W065 | Chromobacterium violaceum. | CviR transcriptional regulator | cviR | HL6, HTF, HL0, HLC | 3QP1, 3QP2, 3QP4, 3QP5 | N/A | link |
P12529 | Citrobacter freundii. | HTH-type transcriptional activator AmpR | ampR | MES | 3KOS | N/A | link |
P94678 | Comamonas testosteroni | HTH-type transcriptional regulator TsaR | tsaR | TSU | 3N6U | N/A | link |
H7C677 | Corynebacterium glutamicum | Full=Probable transcription regulator | N/A | CMP | 4CYD | N/A | link |
Q79VI7 | Corynebacterium glutamicum | Corynebacterium glutamicum ATCC 13032, IS fingerprint type 4-5, complete genome; segment 1/10 | cg0350 | CMP | 3R6S | N/A | link |
Q8NLJ5 | Corynebacterium glutamicum | Corynebacterium glutamicum ATCC 13032, IS fingerprint type 4-5, complete genome; segment 9/10 | cg3261 | MPD | 2DU9 | N/A | link |
Q9PTN2 | Danio rerio | Vitamin D3 receptor A | vdra | XE4, VDX, C5D, G72, H97, 0U3, 0S4, 0VK, 0VO, 0VP, 484, 0VQ, BIV, 4OA | 2HBH, 2HC4, 3DR1, 3O1D, 3O1E, 4FHH, 4FHI, 4G1D, 4G1Y, 4G1Z, 4G20, 4G2H, 4IA1, 4Q0A | N/A | link |
B8J364 | Desulfovibrio desulfuricans | Putative transcriptional regulator, AsnC family | Ddes_0286 | OBV | 4UN1 | N/A | link |
P20153 | Drosophila melanogaster | Protein ultraspiracle | usp | LPP | 1HG4 | N/A | link |
Q82ZT5 | Enterococcus faecalis | Sugar-binding transcriptional regulator, LacI family | EF_2962 | RIB | 4RK0 | N/A | link |
I3TZ89 | Enterococcus faecium DO. | Ribose transcriptional regulator | rbsR | RIB | 4RK1 | N/A | link |
Q2NB98 | Erythrobacter litoralis | Sensor histidine kinase | ELI_04755 | FMN | 3P7N | N/A | link |
P04625 | Gallus gallus | Thyroid hormone receptor alpha | THRA | T3 | 3UVV | N/A | link |
O31408 | Geobacillus stearothermophilus | Arginine repressor | argR | ARG | 1B4B | N/A | link |
Q746X3 | Geobacter sulfurreducens | Proline dehydrogenase and Delta-1-pyrroline-5-carboxylate dehydrogenase | putA | FAD | 4NM9 | N/A | link |
B9UCQ4 | Helicoverpa armigera | Ecdysone receptor | N/A | 834 | 3IXP | N/A | link |
O18473 | Heliothis virescens | Ecdysone receptor | EcR | P1A, HWG, 20E | 1R1K, 1R20, 2R40 | N/A | link |
Q7SIF6 | Heliothis virescens | Gene regulation protein | N/A | EPH | 1G2N | N/A | link |
Q036L9 | Lactobacillus casei | Transcriptional regulator, LacI family | LSEI_2103 | GLC, SUC, TRS | 4RK4, 4RK5, 4WXE | N/A | link |
O26413 | Methanothermobacter thermautotrophicus | Transcriptional regulator | MTH_313 | SAL | 3BPX | N/A | link |
P96896 | Mycobacterium tuberculosis | Leucine-responsive regulatory protein | lrp | PHE, HIS, TYR, TRP, LEU, MET, LYS | 2VBW, 2VBX, 2VBY, 2VBZ, 2VC0, 2VC1, 2W24 | N/A | link |
P9WPY9 | Mycobacterium tuberculosis | Arginine repressor | argR | ARG, GGB | 2ZFZ, 3LAP | N/A | link |
Q9K0L9 | Neisseria meningitidis serogroup B | Transcriptional regulator, AsnC family | NMB0573 | MET, LEU | 2P6S, 2P6T | N/A | link |
P0A4U6 | Nostoc sp. | Global nitrogen regulator | ntcA | AKG, 2FT, BOG | 3LA2, 3LA3, 3LA7 | N/A | link |
O97775 | Pan troglodytes | Androgen receptor | AR | DHT | 1T7R | N/A | link |
E0VFQ5 | Pediculus humanus subsp. corporis | Retinoid X receptor, putative | Phum_PHUM164330 | NEQ | 4OZT | N/A | link |
E0VVT4 | Pediculus humanus subsp. corporis | Ecdysone receptor, putative | Phum_PHUM467460 | P1A | 4OZT | N/A | link |
P25084 | Pseudomonas aeruginosa | Transcriptional activator protein LasR | lasR | OHN, TX1, TX3, TY4 | 3IX3, 3IX4, 3IX8, 3JPU | N/A | link |
P55222 | Pseudomonas aeruginosa | Cyclic AMP receptor-like protein | vfr | CMP | 2OZ6 | N/A | link |
Q9RMS5 | Pseudomonas aeruginosa. | PhzR | phzR | OHN | 3SZT | N/A | link |
Q88PQ6 | Pseudomonas putida | Fructose transport system repressor FruR | fruR | F1X | 3O75 | N/A | link |
O59188 | Pyrococcus horikoshii | Uncharacterized HTH-type transcriptional regulator PH1519 | PH1519; | GLN, ARG, LYS | 2CYY, 2ZNY, 2ZNZ | N/A | link |
P33905 | Rhizobium radiobacter | Transcriptional activator protein TraR | traR | HSL-OOA, LAE | 1H0M, 1L3L | N/A | link |
P55407 | Rhizobium sp. | Probable transcriptional activator protein TraR | traR | LAE | 2Q0O | N/A | link |
Q2RUG3 | Rhodospirillum rubrum | Transcriptional regulator, Crp/Fnr family | Rru_A1431 | HEM | 4K8F | N/A | link |
P72322 | Rhodospirillum rubrum. | CooA protein | cooA | HEM | 1FT9 | N/A | link |
P03069 | Saccharomyces cerevisiae | General control protein GCN4 | GCN4 | C2E-C2E | 3I5C | N/A | link |
P06614 | Salmonella typhimurium | HTH-type transcriptional regulator CysB | cysB | OAS, SAC | 4LQ2, 4M4G | N/A | link |
P25852 | Salmonella typhimurium | Transcriptional regulatory protein ZraR | zraR | ATP | 1OJL | N/A | link |
P40676 | Salmonella typhimurium | Transcriptional regulator SlyA | slyA | SAL | 3DEU | N/A | link |
P52679 | Sphingobium chlorophenolicum. | PCP degradation transcriptional activation protein | pcpR | PCI, T6C | 4RPN, 4RPO | N/A | link |
P0A0N3 | Staphylococcus aureus | HTH-type transcriptional regulator QacR | qacR | MGR, ET, RHQ, DEQ, BER | 3BQZ, 3BR3, 3BR5, 3BT9, 3BTI | N/A | link |
Q6GEG9 | Staphylococcus aureus | Uncharacterized HTH-type transcriptional regulator SAR2349 | SAR2349 | KAN, SAL | 4EM0, 4EM2 | N/A | link |
P0A0N4 | Staphylococcus aureus. | HTH-type transcriptional regulator QacR | qacR | DEQ, CVI, BER, MGR, RHQ, PRL, ET, PNT, DID, BRN | 1JT6, 1JTX, 1JUM, 1JUP, 1JUS, 1QVT, 1QVU, 1RKW, 1RPW, 2GBY | N/A | link |
Q5HLN6 | Staphylococcus epidermidis | Transcriptional regulator TcaR | tcaR | PNN, AIC, MII, KAN, SAL, SRY | 3KP2, 3KP3, 3KP4, 3KP5, 3KP6, 4EJV, 4EJW | N/A | link |
P0A0N5 | Staphylococcus haemolyticus. | HTH-type transcriptional regulator QacR | qacR | CGQ | 2G0E | N/A | link |
Q8E565 | Streptococcus agalactiae serotype III | Redox-sensing transcriptional repressor Rex | rex | NAD | 3KEO | N/A | link |
Q9ADP7 | Streptomyces coelicolor | HTH-type transcriptional repressor SCO4008 | SCO4008; | TLA | 2D6Y | N/A | link |
Q9L2B5 | Streptomyces coelicolor | Putative transcriptional regulator | SCO5405 | SAL | 3ZMD | N/A | link |
Q9XAM6 | Streptomyces coelicolor | Putative transcriptional regulator | SCO6704 | DHB | 4FHT | N/A | link |
Q9XZJ5 | Strongyloides stercoralis | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | N/A | DL4, DL7 | 3GYT, 3GYU | N/A | link |
F9VNT4 | Sulfolobus tokodaii | Glutamine receptor protein | grp | GLN | 2PN6 | N/A | link |
Q96ZY1 | Sulfolobus tokodaii | Putative MarR family transcriptional regulator | STK_17100 | SAL | 3GF2 | N/A | link |
P29283 | Synechococcus elongatus | Global nitrogen regulator | ntcA | AKG | 2XKO | N/A | link |
D5KM69 | Thermoanaerobacter ethanolicus JW 200. | Redox-sensing transcriptional repressor Rex | rex | 8NA, NAI, NAJ | 3WGG, 3WGH, 3WGI | N/A | link |
Q9X2V5 | Thermus aquaticus. | Redox-sensing transcriptional repressor Rex | rex | NAD | 1XCB | N/A | link |
Q5SHS3 | Thermus thermophilus | Redox-sensing transcriptional repressor Rex | rex | NAD | 2DT5 | N/A | link |
Q5SID7 | Thermus thermophilus | Transcription regulator, Crp family | TTHA1437 | CMP | 4EV0 | N/A | link |
Q72I39 | Thermus thermophilus | Redox-sensing transcriptional repressor Rex | rex | NAD | 3IKT | N/A | link |
A1JUG3 | Tribolium castaneum | Ecdysone receptor | ecr-a | P1A | 2NXX | N/A | link |
Q9NCL0 | Tribolium castaneum | Tailless ortholog | N/A | MAL | 4XAI | N/A | link |
A5F384 | Vibrio cholerae serotype O1 | TCP pilus virulence regulatory protein | tcpN | PAM | 3GBG | N/A | link |
Q9KKZ8 | Vibrio cholerae serotype O1 | Transcriptional regulator, LuxR family | VC_A0952 | C2E-C2E | 3KLO | N/A | link |
Q9KQU8 | Vibrio cholerae serotype O1 | Fatty acid metabolism regulator protein {ECO:0000255|HAMAP-Rule:MF_00696} | fadR | 3VV | 4PDK | N/A | link |
Q7MD38 | Vibrio vulnificus | Transcriptional regulator | VVA1198 | BMX | 4IVN | N/A | link |
C5RBT0 | Weissella paramesenteroides ATCC 33313. | Glucose-resistance amylase regulator | ccpA | GLC, SUC | 4RK6, 4RK7 | N/A | link |