SM-TF database

SM-TF is a Small Molecule-Transcription Factor structural database. Transcription Factors (TFs) are proteins involved in the process of transcribing genetic information from DNA to RNA. TFs play crucial roles in the regulation of gene expression. Dysfunction of TFs results in a broad range of diseases. A growing number of TFs have been identified as drug targets.

The SM-TF database collects available 3D structures of small molecule-transcription factor complexes from Protein Data Bank (PDB). Totally, SM-TF contains 934 entries, covering 176 TFs from a variety of species. For each TF, SM-TF provides multiple conformations of binding pockets on the protein and also the structures complexed with different small molecules.

SM-TF serves as a targetable TF database to assist structure-based drug design. The database is suitable for both traditional virtual screening (searching potential ligands for a given target) and inverse virtual screening (searching potential targets for a given ligand).

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Please cite the following reference for the SM-TF database:
Xu X, Ma Z, Sun H, Zou XQ. SM-TF: A structural database of small molecule-transcription factor complexes. Journal of Computational Chemistry, 37: 1559-1564, 2016. [link]